PIPELINE Facility Core Highlight: Dr. Michael Mancini
GC-CPEH Resource Navigator of the Integrated Microscopy Core
Dr. Michael Mancini, professor of molecular and cellular biology and director of Baylor College of Medicine’s long-running Integrated Microscopy Core, serves as the GC-CPEH Resource Navigator for this key PIPELINE facility Core. In a recent breakthrough, Dr. Mancini led a team that used Cell Painting, a high-content imaging technique, to screen 244 plant-derived flavonoids for potential anti-cancer effects on bladder cancer cells. The researchers identified six compounds that selectively killed cancer cells while sparing healthy ones—three of which also reduced tumor growth in 3D models. The findings were published in Pharmacological Research – Natural Products.
“Cell Painting uses high-throughput microscopy to highlight cellular structures and, via custom image analysis pipelines, quantify changes in cultured cell populations,” said Dr. Mancini.